Radiopharmaceuticals

Sodium Iodide I-131

Indication: Diagnostics and thyroid gland treatment: for  an evaluation of  thyroid gland function, scanning and scintigraphy of thyroid gland at various diseases, including for diagnostics of infringement of  thyroid gland functions, and also small-celled cancer of a thyroid gland and metastasises. With a view of therapy, Sodium iodide I-131 is used  for thyrotoxicosis treatment and metastatic cancer of a thyroid gland.

Typical specification of SODIUM  IODIDE  I-131

Appearance

Colorless, transparent solution

pH

7.0-12.0

Radionuclide purity

not more 0.01 % from activity  of  I-131 iodide   for manufacturing date

Radiochemical purity

no less than 95%

Expiry

not more than 15 days

Half-value period

8.02 days

Activity

1 GBq,  2GBq

 

Sodium iodide, I-125

Intended use: Sodium iodide is used in brachytherapy of cancer (prostate and brain), to estimate the glomerular filtration rate and to diagnose deep vein thrombosis, and is also used extensively in the radioimmunoassay.

Specifications of SODIUM IODIDE, I-125

Appearance

Transparent, non-colored fluid

pH

8-11

Radionuclide purity

˃99.9999%

Radiochemical purity

99.20%

Half-life

59.408 days

Packing

From 18.5 GBq

 


ACTINIUM-225, AC-225

Intended use: This is alpha-emitting radionuclide and short-lived product of its dissolution, bismuth-213 (46 minutes); these substances are promising for the treatment of various oncological diseases by means of radiotherapy.

Specifications of ACTINIUM-225, AC-225

Chemical form

Powder or solution of nitrate Ac-225

Radiation type

α, β

Half-life

10 days

Relative activity

With no vehicle - 5.8 * 104 Ci/g

Radionuclide purity

Ra-225 <0.02

Ra-224 <0.02

Th-229 <0.007

Amount of fissionable isotopes: <0.0006

 


THALLIUM-201, TL-201

Intended use: This radionuclide is often used to diagnose coronary heart disease and other heart diseases. This is the most commonly used replacement for Tc-99m. Tl-201 was the main substance for the nuclear cardiography. Moreover, this radionuclide is still being used for stress tests in patient with high risk of coronary heart disease.

Specifications of THALLIUM-201, Tl-201

Chemical form

TL-201, with no vehicle in 0.9% saline solution

Half-life

72.912 hours

рН

5-7

Radionuclide purity

≥98%

Relative activity

≥ 10 mCi/ml

 


Sodium tungstate, W-188

Intended use: W-188 is a parent isotope for the production of W-188/Re-188 generators, designed to produce sterile apyrogenic sodium perrhenate Na188ReO4), which, combined with special kits, is used to synthesize the radiopharmaceutical agents for cancer therapy with simultaneous visualization of the distribution of the agent in the human body.

Specifications, SODIUM TUNGSTATE W-188

Chemical form

Sodium tungstate solution in NaOH (0.5-2.0 mol/l)

Half-life

69.78 days

Relative activity

No more than 3.5 Ci/g

 


PHOSPHORUS-32, Р-32

Intended use: Р-32 is used to diagnose brain tumors, intraocular tumors, breast tumors and some others. P-32 can be used to determine the velocity of blood flow, total volume of red blood cells, amount of circulating blood in cardiovascular diseases, and to diagnose the hematological diseases. Р-32 is considered to be the best known means for treatment of polycythemia, with less efficacy in myeloid leukemia. Moreover, radioactive phosphorus is also used in certain malignant neoplasms: Ewing Sarcoma, osteogenic sarcoma, gallbladder cancer, and bone metastases of breast cancer.

Specifications of PHOSPHORUS-32, Р-32

Chemical form

Orthophosphoric acid, solution in hydrochloric acid 0.04 M

Half-life

14.26 days

рН

6-7

Radionuclide purity

≥99.99%

Relative activity

≥ 8400 Ci/mmol

 


Lutetium chloride, Lu-177

Intended use: Treatment of neuroendocrine tumors with metastases. The drug is intended for IV injections. The patient is also treated with a protective drug to reduce the radiation exposure. The drug has a potent effect in destroying the cancer cells. In some cases, a full recovery occurs, but Lu-177 is mainly used to relieve clinical manifestations of cancer disease.

Specification of LUTETIUM CHLORIDE, LU-177

Chemical form

Lutetium chloride, solution in hydrochloric acid 0.04 M

Half-life

6.734 days

Radiochemical purity

≥99%

Relative activity

≥ 50 Ci/mg

 


STRONTIUM CHLORIDE, SR-89

Intended use: Sr-89 is one of the most effective modern treatment modality, which is used for palliative care in patients with metastatic diasese of prostate, breast, kidneys, and lungs. Sr-89 is also used as an alternative method (or as a additional treatment method combined with external radiation therapy) to relieve the pain syndrome in bone cancer.

Specifications of STRONTIUM CHLORIDE, SR-89

Chemical form

Strontium chloride, solution in hydrochloric acid

Half-life

50.5 days

Concentration activity

33.3-40.7 MBc/ml

Relative activity

˃ 300 Ci/g

 


XENON-133, XE-133

Intended use: In clinical settings, Xe-133 is used for radioisotope diagnostics in the form of an air-xenon mixture and an isotonic solution. Air-xenon (Xe-133) mixture is used as a radioactive indicator in the study of regional pulmonary ventilation, to assess the patency of subarachnoid space and to determine the level and degree of blockade of CSF pathways of the spinal cord. Sterile isotonic solution with Xe-133 is used for quantitative assessment of blood flow in various organs and tissues. In clinical settings, this technique has widely used in evaluation of regional cerebral bloodflow, muscular bloodflow, coronary blood flow, as well as regional bloodflow in the lungs.

Specifications of XENON-133, XE-133

Chemical form

Gas

Half-life

5.27 days

 


MOLYBDENUM-99, MO-99

Intended use: The Mo-99 isotope is the parent isotope in the Tc-99m generator, which is used in the diagnosis of oncological diseases to visualize the skeleton and cardiac muscle, as well as to visualize the brain, the thyroid gland, the lungs (perfusion and ventilation), the gallbladder, the bone marrow, as well as the salivary and lacrimal glands.

Specification of MOLYBDENUM-99, MO-99

Half-life

66.02 hours

рН

7-10

Radionuclide purity

≥ 95%

Relative activity

≥ 27 Ci/mg

 


SAMARIUM-153, SM-153

Indication: Used in oncology with the aim of a persistent reduction in the intensity of the pain syndrome, caused by the presence of metastatic damage bones and for rheumatic patients with severe pain syndrome. Also Sm-153 is very effective in the diagnosis and treatment of prostate and breast cancer.

Typical specification of Sm-153

Half-value period

46,27 hours

рН

5-7

Radionuclide purity

not less than 99,99%

Activity

not less than 240 MBq/ml

 

Tc-99m generator

Indication: Tc-99m generator is intended for multiple production of sterile pyrogen-free sodium pertechnetate in physiological saline solution (0,9% NaCl).

Typical specification of Tc-99m generator

Parent Isotope activity

4 GBq, 6 GBq, 8 GBq, 11 GBq, 19 GBq

Appearance

Colorless, transparent solution

Radioactive concentration

74-3700 MBq/ml

pH

4,0-7,0

Radiochemical purity

not less than 99.0%

Expiry

15 days from the production date

Generator weight

16 kg (weight of generator including the package)

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