Lutetium-177

R001
Lutetium-177 is beta-minus emitter, that is very popular in radionuclidic therapy. CMR supplies with carrier-free Lutetium-177, suitable to the requirements of EP monograph 2798 "Lutetium ¹⁷⁷Lu solution for radiolabeling"

CMR Product code: R001

Grade:
1. Non-carrier added radionuclide;
2. GMP product;
3. Tested for sterility and bacterial endotoxins.

Chemical form: ¹⁷⁷Lu chloride solution in 0.04 HCl
Radiochemical purity: > 99%
Specific activity, Ci/mg: > 81.08
Half-life period: 6.65 days
Production methods

Production methods

1. LU-176 (N, Γ) ¹⁷⁷Lu
The ¹⁷⁶Lu isotope is irradiated in a reactor and is produced by direct reaction ¹⁷⁶Lu (n,γ) ¹⁷⁷Lu As a result – ¹⁷⁷Lu with a sufficiently high specific activity. However, this method has a number of disadvantages:
  • As a result – ¹⁷⁷Lu with carrier, which limits its sphere of application in nuclear medicine.
  • This method leads to appearance in the received ¹⁷⁷Lu impurity long-lived activity of Lu-177m with a half-life of 160 days.

2. ¹⁷⁶Yb (N, Γ) ¹⁷⁷Yb→ ¹⁷⁷Lu
The ¹⁷⁷Lu isotope is obtained by the reaction ¹⁷⁶Yb (n,γ) ¹⁷⁷Yb followed by beta decay ¹⁷⁷Yb till ¹⁷⁷Lu. Compared with the previous method, this method has several advantages:
  • When implementing this scheme, theoretical specific activity is much higher than in the previous method.
  • In the implementation of this scheme, ¹⁷⁷Lu is formed without a “harmful” carrier.
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